Jiangsu Hansoh Pharmaceutical Co., Ltd.
Morinidazole was approved by China Food and Drug Administration (CFDA) on February 24, 2014. It was developed and marketed as a step Lingda ® by Hansoh Pharmaceutical.
A nitroimidazoles antibiotic used to treat bacterial infections including appendicitis and pelvic inflammatory disease.
1- (2,3-epoxypropoxy yl) -2-methyl-5-nitro-imidazole (10g), morpholino (10g), 100ml of acetonitrile under reflux for 2 hours, vacuum recovery of acetonitrile, water was added 100ml, heating to the whole solution, filtered hot, let cool, filtering, washing and drying to obtain an off-white solid (11g).
Proton nuclear magnetic resonance data: 1HNMR (CD3Cl) δ2.39 ~ 2.73 (6H, m) δ2.61 (3H, s) δ3.71 ~ 3.81 (4H, m) δ4.10 ~ 4.17 (2H, m) δ4 .63 ~ 4.66 (1H, m) δ8.00 (1H, s)
Example 7 Preparation of α- (morpholino-1-yl) methyl-2-methyl-5-nitroimidazole-1-ethanol according to Example 4 the same manner as in Preparation α- (morpholino-1-yl) methyl-2-methyl-5-nitroimidazole-1-ethanol, except for using morpholine instead of 4-hydroxypiperidine, prepared by the present invention Compound 7. Proton nuclear magnetic resonance data: 1HNMR (CD3Cl) δ2.39 ~ 2.73 (6H, m) δ2.61 (3H, s) δ3.71 ~ 3.81 (4H, m) δ4.10 ~ 4.17 (2H, m) δ4
1H NMR PREDICT
13C NMR PREDICT
|CN1810815B||Mar 8, 2006||Mar 16, 2011||陕西合成药业有限公司||Nitroimidazole derivative for treatment|
|CN1903846B||Aug 15, 2006||Jul 13, 2011||杨成||Ornidazole derivative used for therapy, its preparation method and use|
|CN100387233C||Jun 9, 2006||May 14, 2008||南京圣和药业有限公司||Use of levo morpholine nidazole for preparing medicine for antiparasitic infection|
|CN100427094C||Dec 13, 2005||Oct 22, 2008||江苏豪森药业股份有限公司||Usage of alpha-(Morpholin-1-base) methyl-2-methyl-5-azathio-1-alcohol in preparation of anti-trichomoniasis and anti-ameba medicines|
|CN100540549C||Dec 15, 2005||Sep 16, 2009||南京圣和药业有限公司||Alpha-substituted-2-methyl-5-nitro-diazole-1-alcohol derivative with optical activity|
|WO2007079653A1 *||Dec 25, 2006||Jul 19, 2007||Junda Cen||OPTICALLY PURE α-SUBSTITUTED 2-METHYL-5-NITROIMIDAZOLE-1-ETHANOL DERIVATIVES|